Rabbi Klatzko attended Telshe Yeshiva in Cleveland and received his rabbinic ordination from Mir Yeshiva in Brooklyn, New York from Rabbi Shmuel Berenbaum, ZTL. Rabbi Klatzko accepted an offer to serve as Rabbi of the 14th ave Agudath Israel of Brooklyn, New York and Shaarey Tzedek Congregation in Perth Amboy, New Jersey. Rabbi Klatzko has been involved in campus outreach the past two decades as part of Olami.

Rabbi Benzion Klatzko also founded the website Shabbat.com to facilitate shabbos and shidduch connections across the globe. Today, Shabbat.com is the largest Jewish Social Network in the world. Endorsed by the gedolim and active in 148 countries, 10,000 people a week take advantage of the Shabbat.com service.

Rabbi Klatzko, his wife Shani, and their 11 children currently live in Monsey, New York, where hosting 70 or more people for Shabbos in the norm. He has been at the frontier of improving Jewish communal life.